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在MAML2-重新排列的粘膜皮瘤癌中PD-L1表达的异质性

Bacem Abdullah¹, Osama A M Al Qeshty¹, Sherif Y El-Nagdy²

¹Department of Oral Pathology, Faculty of Dentistry, Mansoura University, Egypt.

Pathology, research and practice

|December 13, 2023

概括

编程死亡配体1 (PD-L1) 表达在粘膜皮质癌 (MEC) 亚型之间有所不同,其中一些表达更高. 这种PD-L1的变化可以预测MEC患者的生存结果.

科学领域:

在瘤学瘤学.
病理学病理学病理学
免疫学免疫学免疫学

背景情况:

粘膜皮质瘤 (MEC) 呈现出多样化的形态和分级挑战.
在MEC的预测指标并不总是清晰的.
了解瘤生物学,包括免疫标志物表达,对于MEC至关重要.

研究的目的:

在MEC的各种等级和表型中研究编程死亡配体1 (PD-L1) 表达.
为了将PD-L1表达与MEC的临床病理特征相关联.

主要方法:

对24个档案唾液MEC样本的分析.
使用光 in situ 杂交,检测MAML2重组的情况.
针对PD-L1表达的免疫组织化学染色,按MEC等级和表型分类.

主要成果:

在MEC中PD-L1表达表明了亚型之间的变异性.
华类MEC显示混合的高和低PD-L1表达.
骨内MEC表现出中度的PD-L1表达,而硬化和瘤细胞MEC显示出较低的水平.

结论:

组织形态学特征和MEC的亚型对预测行为和治疗策略有价值.
PD-L1表达是MEC中生存结果的重要预测因素.

关键词:

鱼类鱼类是一种鱼类.在MAML2中重新排列.粘膜皮质细胞癌是什么?硬化MEC的MEC是多样化的类似于温的薄型.

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