来自Sonchus arvensis L的总黄素通过调整肠道微生物群来改善结肠炎
Yachao Ren1,2, Shenghua Hou2, Jing He2
1School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin, China.
Annals of medicine
|December 13, 2023
概括
来自Sonchus arvensis L. (SAF) 的黄保护小鼠免受硫酸 (DSS) 诱导的结肠炎. 治疗SAF改善了肠道微生物群的多样性,这表明肠道细菌和结肠炎改善之间存在联系.
科学领域:
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- Sonchus arvensis L. 在中国传统医药和美食中使用.
- 炎症性肠道疾病,如结肠炎,对健康构成重大挑战.
- 肠道微生物群失生症与大肠炎的发病有关.
研究的目的:
- 为了研究Sonchus arvensis L. flavones (SAF) 对小鼠硫酸 (DSS) 诱导的大肠炎的保护作用.
- 探索肠道微生物群 (GM) 调节在SAF治疗作用中的作用.
主要方法:
- C57BL/6小鼠接受了DSS来诱导大肠炎,并接受了SAF或阳性对照的治疗.
- 通过临床观察 (体重,便一致性,血液),结肠长度,组织学和疾病活性指数 (DAI) 来评估有效性.
- 用16S rRNA基因测序分析了肠道微生物组成.
主要成果:
- 在DSS诱导的大肠炎小鼠中,SAF显著减轻了体重减轻,并降低了DAI得分.
- 用SAF治疗改善了结肠长度,改善了病理变化和血液参数.
- 16S rRNA测序表明,SAF调节了肠道微生物群,显著增加了Akkermansia的丰富性.
结论:
- 在小鼠模型中,Sonchus arvensis L. flavones显示出对DSS诱导的大肠炎的保护作用.
- SAF的治疗效益可能与肠道微生物群多样性的调节有关,特别是Akkermansia属.
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