在非小细胞肺癌中,炎症和基于营养的评分的预后值在非小细胞肺癌中
Mert Erciyestepe1, Oğuzhan Selvi1, Şermin Dinç Sonuşen1
1Sağlık Bilimleri University Professor Dr. Cemil Taşcıoğlu City Hospıtal, Department of Medical Oncology, Istanbul, Turkey.
炎症和营养评分如NLR,PLR,PNI和mGPS预测非小细胞肺癌 (NSCLC) 患者的生存率和疾病进展. 这些易于获取的标志物为NSCLC结果提供了有价值的预后信息.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 免疫学 免疫学 免疫学
背景情况:
- 系统性炎症显著影响癌症的进展,包括非小细胞肺癌 (NSCLC) 的扩散,迁移,入侵和转移.
- 炎症和基于营养的预后得分越来越多地被认为与NSCLC患者的生存结果有关.
研究的目的:
- 评估炎症和基于营养的评分对NSCLC患者的生存和疾病进展的预后影响.
- 在NSCLC中确定中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR),预后营养指数 (PNI) 和修改格拉斯哥预后得分 (mGPS) 的预测值.
主要方法:
- 在102名被诊断为1,2,3A期NSCLC的患者中,对NLR,PLR,PNI和mGPS值进行了回顾性分析.
- 统计分析以评估这些得分与死亡率,局部区域复发和远程转移有关的意义.
主要成果:
- 在NLR,PLR,PNI和mGPS中,死亡率组之间存在统计学上显著的差异 (p<0.001对于NLR和PNI,p=0.001对于PLR和mGPS).
- 在没有生存的患者中观察到较高的NLR和PLR,而较高的PNI与生存有关.
- 所有四个评分 (NLR,PLR,PNI,mGPS) 都显示出与局部区域复发的显著关联,PNI和mGPS是远程转移发展的显著预测因素.
结论:
- NLR,PLR,PNI和mGPS是易于获取的,非侵入性参数,可以提供有关NSCLC存活率和疾病进展的重要预测信息.
- 这些基于炎症和营养的得分有效预测预后,并可以帮助进行NSCLC管理的临床决策.
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