Bifidobacterium longum促进了肝细胞癌患者手术后的肝功能恢复
Jingjing Yu1, Peng Zhu2, Linlin Shi3
1Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Hubei Key Laboratory of Hepato-Pancreatic-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Cell host & microbe
|December 13, 2023
概括
手术后恢复肝功能对于肝癌患者至关重要. 在临床试验中,补充Bifidobacterium longum,一种肠道微生物,显著改善了肝脏的恢复,减少了住院时间,并提高了生存率.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 及时恢复肝功能 (LFR) 对接受肝细胞癌 (HCC) 手术的患者至关重要.
- 延迟的LFR与HCC患者的长期生存率较差有关.
- 肠道微生物群在肝切除术后恢复中的作用仍然不完全理解.
研究的目的:
- 研究肠道微生物群对HCC患者的LFR的影响.
- 确定影响LFR的特定微生物物种.
- 评估调节肠道微生物群的治疗潜力,以改善HCC的术后结果.
主要方法:
- 追溯和前性队列研究,以确定LFR的意义.
- 在小鼠身上移植便微生物群,以评估肠道微生物对恢复的影响.
- 临床试验中,给HCC患者服用含有Bifidobacterium longum的益生菌尾酒.
主要成果:
- Bifidobacterium longum被确定为一个关键的肠道微生物,在LFR延迟的患者中被耗尽.
- 在肝切除术后的小鼠中,B. longum的口服测量改善了肝功能和修复.
- 临床试验显示,B. longum的使用减少了延迟康复率,缩短了住院时间,并改善了1年生存率.
结论:
- 肠道微生物群调节,特别是Bifidobacterium longum,可以增强HCC患者的LFR.
- 改善的LFR与减少肝炎,纤维化和增强的肝细胞增殖有关.
- 针对肠道微生物群提供了一个有希望的策略,以改善HCC患者的术后结果.
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