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Updated: Jul 8, 2025

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
08:52

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Published on: November 22, 2021

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通过激活ErbB3/STAT3信号通路,CD44s和CD44v8-10异型通过激活ErbB3/STAT3信号通路,赋予了对奥西默蒂尼布的获得性耐药性

Yi-Nan Liu1, Meng-Feng Tsai2, Shang-Gin Wu3

  • 1Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Life sciences
|December 13, 2023
PubMed
概括

CD44拼接变体通过合作选择ErbB3信号通路,在肺癌中驱动获得的对 osimertinib 的耐药性. 针对CD44/ErbB3信号提供了一个潜在的策略来克服这种阻力.

关键词:
获得的电阻 获得的电阻这种CD44异型是CD44异型.肺癌是一种肺癌.奥西默蒂尼布 (Osimertinib) 是一种药物.

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