血类昆与中国高血压成年人全因死亡率之间的负相关性:一项嵌套病例对照研究
Yaping Wei1, Qiangqiang He2, Hehao Zhu3
1College of Public Health, Shanghai University of Medicine and Health Sciences, Shanghai, China.
The Journal of nutrition
|December 13, 2023
概括
较高的血基因水平与高血压的中国成年人全因死亡风险降低有关. 这种保护性关联在具有较高体重指数 (BMI) 的个体中尤为明显.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 老年学是指老年学的学科.
背景情况:
- 维生素K,特别是基,对于预防慢性疾病至关重要.
- 有限的数据存在于血类基和所有原因死亡率之间的关联.
研究的目的:
- 调查血类类水平与因任何原因死亡的风险之间的关系.
- 探索影响这种关联的潜在混因素.
主要方法:
- 从RCT中使用嵌套病例控制设计的后期分析.
- 包括604个死亡病例和604个来自高血压参与者的匹配对照.
- 使用LC-MS/MS测量了血类昆,并分析了逻辑回归的死亡风险.
主要成果:
- 在血类和全因死亡率 (OR:0.79;95%CI:0.66,0.95) 之间发现了显著的反向关联.
- 这种关联因BMI而异,在BMI≥25kg/m2 (OR:0.71;95%CI:0.56,0.90) 的个体中观察到更强的保护作用.
- 在BMI<25 kg/m2的参与者中没有发现显著的关联.
结论:
- 血类昆与中国高血压患者的全因死亡率有负面关联.
- 这种关联在BMI较高的个体中更为显著,这表明它在心血管健康管理中可能发挥作用.
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