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通过基于生理的动力学和生物能量学建模预测鸟类的繁殖毒性

Thomas Martin¹, Barbara Bauer¹, Vanessa Baier²

¹Rifcon GmbH, Goldbeckstraße 13, 69493 Hirschberg an der Bergstraße, Germany.

The Science of the total environment

|December 13, 2023

概括

动态能源预算-毒性催化剂-毒性动力学 (DEB-TKTD) 模型准确地预测了农药对北方白长繁殖的影响. 这项研究证明了它们在对鸟类的环境风险评估 (ERA) 中的有用性.

科学领域:

生态毒理学生态毒理学
环境风险评估 (ERA) 环境风险评估
计算毒理学计算毒理学

背景情况:

农药对鸟类繁殖的影响对于环境风险评估 (ERA) 至关重要.
动态能源预算-毒性催化剂-毒性动力学 (DEB-TKTD) 模型为ERA提供了机制预测.
需要进行案例研究来验证DEB-TKTD模型对鸟类风险评估的有效性.

研究的目的:

为了模拟扎米德的作用,一个皮拉姆代谢物,在北方白 (Colinus virginianus).
为了证明DEB-TKTD模型在鸟类生殖毒性评估中的应用.
将暴露建模与毒动力学建模相结合,以改善ERA预测.

主要方法:

一个DEB-TKTD模型的参数化,使用北方白长胚胎的卵注射研究.
开发一种基于生理学的毒动力学 (PBK) 模型,以预测通过饮食摄入产生的内部蛋暴露.
整合DEB-TKTD和PBK模型,以预测对幼和小体重的影响.

主要成果:

模型校准表明本扎米德通过黄体吸收,并对能量同化/动员施加压力.
结合的DEB-TKTD和PBK模型准确地预测了小的体重减少.
不同的TKTD假设需要特定的终点数据 (存活率,生长率,蛋黄利用率) 来进行模型歧视.

结论:

由实验数据和暴露模型支持的DEB-TKTD模型可以可靠地预测农药对鸟类繁殖的影响.
这种方法提高了机械模型在鸟类环境风险评估中的实用性.
该研究为使用DEB-TKTD模型在禽类ERA中提供了经过验证的框架.

关键词:

飞行员飞行员飞行员飞行员动态能源预算是一个动态能源预算.环境风险评估环境风险评估杀虫剂是一种杀虫剂.基于生理学的动力学.在 TKTDD 找 TKTD

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