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封闭后反应性高血压变量可用于诊断出血动冲击中的血管功能障碍

Aleksey Dubensky¹, Ivan Ryzhkov¹, Zoya Tsokolaeva¹

¹Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.

Microvascular research

|December 13, 2023

概括

在老鼠中,出血性休克会导致皮肤血液流量减少和闭塞后反应性高血症,以及血管导电率增加. 这项研究揭示了冲击期间早期的微血管变化.

科学领域:

生理学生理学生理学
血液动力学血液动力学
微循环是一种微循环.

背景情况:

激光多普勒流量计 (LDF) 非侵入性地评估了微血管功能.
带有LDF的封闭后反应性高血压 (PORH) 提供了有关血管运动功能和血液流量储备的见解.

研究的目的:

在出血性休克 (HS) 期间检测老鼠皮肤中PORH变量的早期变化.

主要方法:

雄性Wistar大鼠接受了麻醉和导管治疗,以监测平均动脉压 (MAP).
后肢上的LDF探头,气动袖子用于3分钟的遮;在基线和出血后30分钟的测量.
由30%的抽血引起的出血性休克;假装组没有流血.

主要成果:

出血性休克显著降低了MAP,平均皮肤血流量 (M) 和峰值高血 (Mmax).
皮肤血管导电性 (CVC) 和最大CVC (CVCmax) 在HS组显著增加.
通过动脉血液气体分析,在HS组中明显出现了代谢性乳酸.

结论:

在老鼠中,出血性休克会改变皮肤血液流动,降低 perfusion (M) 和 PORH 强度 (Mmax).
同时,在出血性休克期间,血管导电率 (CVC和CVCmax) 增加.
这些发现突出了早期的微血管调整,以应对HS.

关键词:

急性失血是指急性失去血液的情况.皮肤上的微循环.血流性休克是一个令人震惊的现象.葡萄牙的葡萄牙.鼠标鼠标鼠标鼠标

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