相关实验视频

Updated: Jul 8, 2025

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

Published on: May 10, 2016

使用网络毒性模型评估多环芳的生态影响石油污染物

Shiqi Wang¹, Congcong Li², Lisheng Zhang³

¹School of Energy, Faculty of Engineering, China University of Geosciences, Beijing, 100083, PR China.

Environmental research

|December 13, 2023

概括

具有较高分子量的多环芳 (PAH) 对人类健康和水生生态系统构成更大的风险. 网络毒性模型揭示了关键化合物和途径,有助于评估生态风险.

科学领域:

环境毒理学环境毒理学
计算化学计算化学
生态毒理学生态毒理学

背景情况:

多环芳 (PAH) 是持久性石油污染物,对人类健康和生态系统产生重大影响.
由于成本,时间和复杂的分析要求,评估PAH毒性具有挑战性.
了解PAH毒性机制对于有效的风险管理至关重要.

研究的目的:

通过网络毒性模型,分析PAHs在化合物,基因,途径和物种层面的毒性机制.
通过使用最大可接受度 (MAC) 和风险系数 (RQ) 值来评估PAHs的潜在生态风险.
评估网络毒性模型对PAH风险评估的适用性.

主要方法:

网络毒性建模网络毒性建模
丰富分析是一种丰富分析.
分子对接是分子对接.
最大可接受度 (MAC) 和风险系数 (RQ) 的计算.

主要成果:

较高分子量PAHs表现出增加的脂友性和毒性.
[a]和被确定为通过像CCND1.1.这样的基因影响癌症风险的核心化合物.
酸对水生生物的影响比陆地生物更为严重,在黄河三角洲等地区的生态风险更高.

结论:

网络毒性模型提供了一种强大的方法来阐明PAH毒性机制和物种特异性影响.
结果为PAH监测,预防策略和生态风险评估提供了关键的见解.
高分子量PAHs对人类健康和水生环境都造成了重大关注.

关键词:

生态风险评估评估生态风险评估分子对接是分子对接.网络毒性模型网络毒性模型多环芳香碳化合物多环芳香碳化合物

更多相关视频

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

Published on: August 28, 2019

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Published on: February 12, 2015

相关概念视频

Types of Toxins

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...

Bioremediation

Bioremediation

Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.