气体协同光疗的当前趋势,以改善抗瘤疗法
Ziwei Yan1, Zhu Liu1, Haotian Zhang2
1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning Province 110016, PR China.
Acta biomaterialia
|December 13, 2023
概括
将气体与光疗相结合,可以改善癌症治疗. 氧化 (NO) 和一氧化碳 (CO) 等气体可以提高光热疗法 (PTT) 和光动力疗法 (PDT) 的疗效,改善瘤细胞死亡和减少炎症.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 光疗 (PTT,PDT) 提供最少的侵入性癌症治疗,但在疗效和临床转化方面面临挑战.
- 气体剂 (NO,CO,H2S) 由于其独特的生物功能,在协同的癌症治疗中表现有前途.
- 将气体与光疗相结合可以克服固有的局限性并提高治疗结果.
研究的目的:
- 综合审查癌症治疗的气体协同光疗的最新进展.
- 总结协同机制,纳米平台设计,多式疗法和成像指导.
- 在这个治疗领域讨论当前的挑战和未来的机会.
主要方法:
- 关于气体协同光疗策略的现有文献的审查.
- 分析气体与光疗之间的协同机制 (PTT/PDT).
- 检查纳米平台设计的增强气体输送和治疗效果.
- 探索多模式和成像引导的治疗方法.
主要成果:
- 气体增强PTT热损伤和PDT反应性氧物种 (ROS) 生产.
- 气体光疗组合改善了光活性剂的瘤积累,并抑制了炎症.
- 新型纳米平台集成成像和治疗,以获得先进的超神能力.
- 协同作用的机制包括直接杀死瘤细胞和调节瘤微环境.
结论:
- 气体协同光疗是一种有希望的策略,可以克服传统光疗的局限性.
- 纳米平台的合理设计对于优化治疗疗效和治疗潜力至关重要.
- 对协同机制和临床转化进行进一步的研究是有效的瘤治疗的必要条件.
相关概念视频
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
01:27Tumor Immunotherapy
529
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
529
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
01:30Cancer Vaccines
376
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
376