最近在二氧化硫方面的进展释放了用于癌症治疗的纳米平台
Pan He1, Xiaoyue Ren1, Yu Zhang2
1School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, PR China.
Acta biomaterialia
|December 13, 2023
概括
二氧化硫 (SO2) 气体疗法通过使用纳米平台为SO2捐赠者提供治疗癌症的希望. 这种方法利用SO2作为杆.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 二氧化硫 (SO2) 被公认为具有重要的病理生理作用的第四种气体传递物.
- 基于SO2的气体治疗正在成为一种新的癌症治疗策略.
- SO2充当谷氨的消费者,诱导反应性氧物种和氧化应激导致癌细胞死亡.
研究的目的:
- 在过去十年中,审查纳米平台在癌症治疗中控制二氧化硫 (SO2) 释放的进展.
- 总结SO2预药物和纳米载体的开发,用于瘤特定的输送.
- 讨论涉及SO2气体治疗和其他癌症治疗方法的组合策略.
主要方法:
- 合成聚和宏分子SO2前药物,形成纳米粒子.
- 开发具有小分子SO2捐赠体 (醇激活,酸敏,光敏) 的刺激响应纳米平台.
- 综合疗法的审查,包括使用光动力学,化疗,光热,声动力学和纳米催化剂方法的SO2气体疗法.
主要成果:
- 纳米平台可以在瘤微环境中控制SO2的释放.
- 聚二氧化预药物显示出克服多药耐药性的潜力.
- 刺激响应的SO2捐赠体和组合疗法证明了瘤抑制的有效性.
结论:
- 纳米平台结合SO2前药物和捐赠者为癌症治疗提供了一个有希望的策略.
- 通过纳米载体控制SO2释放可以增强抗癌效应.
- 对基于SO2的气体疗法的进一步研究有可能克服当前的癌症治疗挑战.
更多相关视频
07:54Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
Published on: March 25, 2019
8.2K
05:55Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
Published on: September 18, 2018
8.8K
相关概念视频
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K