从SABR对细胞癌的体积反应评估的评估
Daniel G Schep1, Jasmin Vansantvoort2, Ian Dayes1
1Juravinski Cancer Centre, Hamilton, Ontario, Canada; McMaster University, Hamilton, Ontario, Canada.
International journal of radiation oncology, biology, physics
|December 13, 2023
概括
体积测量显示较早和更大的变化比线性大小,以评估细胞癌 (RCC) 治疗应答后的立体性废除性放射治疗 (SABR). 这有助于指导RCC患者的后续护理.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医疗成像医学成像
背景情况:
- 立体除性放射疗法 (SABR) 是对细胞癌 (RCC) 的新兴治疗方法.
- 对RCC进行SABR后治疗反应评估的最佳方法尚未确定.
- 评估瘤变化对于有效的RCC管理至关重要.
研究的目的:
- 在SABR之后量化RCC瘤的体积和线性尺寸变化.
- 为了比较体积与线性尺寸测量的实用性,评估SABR治疗反应.
- 为监测用SABR治疗的RCC患者提供指导.
主要方法:
- 用SABR (2013-2020) 治疗的RCC患者的回顾性分析.
- 计算机断层扫描 (CT) 扫描用于测量瘤体积和随访时最大线性大小.
- 测量结果与基线CT模拟扫描结果进行了比较.
主要成果:
- 在25个瘤中,有19个 (76%) 在SABR.BR后7个月内显示出30%的体积反应.
- 在25个瘤中,12个 (48%) 显示SABR后16个月的线性大小减少为30%.
- 与T1a瘤相比,较大的瘤 (T1b+) 在24个月后显示出更短暂的生长和更大的体积.
结论:
- 对RCC的体积测量评估显示了比SABR后的线性尺寸测量更早,更显著的变化.
- 体积测量是治疗反应的更敏感的指标.
- 这些发现支持使用体积变化来监测SABR后的RCC患者.
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