基于血液的炎症指数与精神分裂症患者的临床评分之间的关系:一个横截面研究
Mohammad-Shafi Mojadadi1, Mojtaba Mahjour2, Hossein Fahimi3
1Department of Immunology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Behavioural brain research
|December 13, 2023
概括
通过中性粒细胞与淋巴细胞比率 (NLR) 和全身炎症指数 (SII) 测量的炎症与精神分裂症症状有关. 这些血液标记物可能有助于评估患者的疾病严重程度和炎症状况.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症是一种严重的精神障碍,可能涉及炎症.
- 像NLR,MLR,PLR和SII这样的炎症指数是与各种疾病相关的简单措施.
- 很少有研究比较这些指数及其与精神分裂症症状的关系.
研究的目的:
- 调查基于血液的炎症指数和精神分裂症患者的临床症状之间的相关性.
- 将这些指标的预测值与不同症状尺寸进行比较.
- 探索这些协会中潜在的性别差异.
主要方法:
- 这是一项对121名精神分裂症患者的横截面研究.
- 测量中性粒细胞与淋巴细胞比率 (NLR),单细胞与淋巴细胞比率 (MLR),血小板与淋巴细胞比率 (PLR) 和全身炎症指数 (SII).
- 使用阳性和阴性综合征量表 (PANSS) 评估临床症状.
- 统计分析包括相关性和回归,并按性别分组分析.
主要成果:
- 所有测试的炎症指数 (NLR,MLR,PLR,SII) 与PANSS总,正,负和一般精神病理学分数 (P <0.02) 有正相关.
- 观察到性别特异性差异:男性显示所有指数和所有分数之间的相关性,而女性仅显示NLR和SII的相关性.
- 在对混因素进行调整后,NLR预测了所有PANSS得分,SII预测了总和一般精神病理学得分.
结论:
- 炎症在精神分裂症的病理生理学和临床表现中起作用.
- 基于血液的炎症指数,特别是NLR和SII,可以作为精神分裂症炎症状况和症状严重性的指标.
- 这些指数可能被用作对精神分裂症患者的查工具.
更多相关视频
相关概念视频
Biological Causes of Schizophrenia
59
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
59
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
95
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
95
Psychological and Sociocultural Causes of Schizophrenia
91
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
91
Negative and Cognitive Symptoms of Schizophrenia
49
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
49
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
335
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
335
Schizophrenia
89
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
89


