肝炎B核心相关抗原动态和后续临床复发的风险在核化类比停止后
Ying-Nan Tsai1,2, Jia-Ling Wu3, Cheng-Hao Tseng1,2
1Division of Gastroenterology and Hepatology, E-Da Cancer Hospital, I-Shou University, Kaohsiung, Taiwan.
Clinical and molecular hepatology
|December 13, 2023
概括
在核胺类同类 (NA) 治疗停止后测量乙型肝炎核心相关抗原 (HBcrAg) 可以预测慢性乙型肝炎 (CHB) 患者的临床复发 (CR). 较低的HBcrAg水平 (<1,000 U/mL) 表明复发风险降低,有助于治疗后的监测.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 生物标志物发现发现
背景情况:
- 有限核酸类比 (NA) 疗法正在研究慢性乙型肝炎 (CHB).
- 在NA停止后监测CHB患者的生物标志物有限.
- 乙型肝炎核心相关抗原 (HBcrAg) 是治疗后监测的潜在标志物.
研究的目的:
- 评估NA停止后的B型肝炎核心相关抗原 (HBcrAg) 水平是否可以对CHB患者随后临床复发 (CR) 的风险进行分层.
- 确定HBcrAg对CHB治疗后结果的预测值.
主要方法:
- 对患有CHB的成年人进行回顾性多中心分析.
- 患者停止服用恩特卡维尔或诺福维尔,HBV DNA无法检测,HBeAg.阴性.
- 时间依赖的考克斯比例危险模型分析了HBcrAg水平和CR之间的关联.
主要成果:
- 分析了203名CHB患者,随访时间中位数为31.7个月.
- 五年累计的CR发生率为54.8%.
- 随时间变化的HBcrAg水平显著预测了CR (aHR,每日志单位/毫升1.53);<1,000单位/毫升的水平与较低的CR风险相关 (aHR,0.41).
结论:
- 在NA停止后对HBcrAg的动态测量是随后CR的重要预测指标.
- 对HBcrAg的监测可以帮助分层风险,并指导CHB患者的治疗后监测策略.
- 在有限的NA治疗后,HBcrAg提供了管理CHB患者的宝贵工具.
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