在患有阻塞性睡眠呼吸暂停的儿童中,循环血压失调
Md Tareq Ferdous Khan1,2, David F Smith3,4,5,6, Christine L Schuler4,7,8
1Division of Biostatistics and Bioinformatics, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Sleep
|December 13, 2023
概括
患有中度至重度阻塞性睡眠呼吸暂停 (OSA) 的儿童表现出较早的血压 (BP) 峰值和最低点,以及血压升高和不下降的模式,表明昼夜BP节律受损.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 睡眠医学 睡眠医学
- 循环节生物学 日间生物
背景情况:
- 已知阻塞性睡眠呼吸暂停 (OSA) 对血压 (BP) 调节产生负面影响.
- 在正常的昼夜血压模式中出现的干扰是OSA的潜在后果.
- 了解儿童的这些障碍对于管理长期心血管健康至关重要.
研究的目的:
- 为了研究和比较被诊断患有OSA的儿童的24小时昼夜血压节律,与健康对照对比.
- 为了确定与儿童群体OSA相关的BP模式的特定变化,例如峰值和最低点的时间.
主要方法:
- 在5-14岁儿童中使用了24小时的门诊血压监测和动图.
- 采用形状不变的统计模型来分析和比较OSA和对照组之间的昼夜血压模式.
- 量化参数包括BP峰值的时间和达到峰值BP速度 (TAPV) 的时间.
主要成果:
- 与对照组相比,患有中度至重度OSA (MS-OSA) 的儿童在缩血压 (SBP) 和腹血压 (DBP) 方面表现出明显较早的TAPV.
- 在MS-OSA小组中,早些时候的BP峰值和最低点在白天和晚上出现.
- 在MS-OSA组在特定时期观察到SBP和DBP升高,并且"不浸泡"模式的流行率更高.
结论:
- 患有MS-OSA的儿科患者表现出昼夜血压模式的显著变化,其特点是较早的血压峰值,最低点和TAPV.
- 这些昼夜血压障碍很可能是患有OSA的儿童血压调节障碍发展的组成部分.
- 这些发现强调了评估昼夜BP节律在儿科OSA的管理中的重要性.
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