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Updated: Jul 8, 2025

Using the E1A Minigene Tool to Study mRNA Splicing Changes
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由原蛋白触发的转录组重编程通过替代拼接驱动三阴性乳腺癌的细胞死亡

Meenakshi Sudhakaran1, Tatiana García Navarrete2, Katherine Mejía-Guerra3

  • 1Molecular, Cellular, and Integrative Physiology Graduate Program, Michigan State University, East Lansing, MI, USA.

Cell death & disease
|December 13, 2023
PubMed
概括

黄类型的阿皮根因在三阴性乳腺癌 (TNBC) 中重新编程替代拼接 (AS). 这种营养药物将异常的癌症转录组转移到正常模式,减少瘤生长并增加亡.

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Alternative RNA Splicing

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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