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Updated: Jul 8, 2025

Monitoring the Assembly of a Secreted Bacterial Virulence Factor Using Site-specific Crosslinking
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在细菌外膜接口上的脂运输的分子机制

Jiang Yeow1, Min Luo2,3, Shu-Sin Chng4,5

  • 1Department of Chemistry, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore.

Nature communications
|December 13, 2023
PubMed
概括

OmpC-Mla系统通过运输错位的脂物来维持细菌外膜的完整性. 这项研究揭示了MlaA和MlaC如何相互作用,以促进这一关键的脂质运输过程.

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Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
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Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
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