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基于的代谢性寡糖的工程策略,用于定量检测甘氨酸

Xiao Tian1, Lingna Zheng2, Changjiang Wang1

  • 1State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, China.

Nature communications
|December 13, 2023
PubMed
概括

基于的代谢性寡糖体工程 (SeMOE) 能够精确地检测和量化甘氨酸. 这种新策略简化了甘氨酸分析,以便进行更广泛的生物探索.

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Oligosaccharide Assembly01:24

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Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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