皮层微结构协会与CSF粉样蛋白和pTau
Talia M Nir1, Julio E Villalón-Reina2, Lauren E Salminen2
1Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. tnir@usc.edu.
Molecular psychiatry
|December 13, 2023
概括
扩散MRI (dMRI) 揭示了阿尔茨海默病 (AD) 中的微观结构性大脑变化. 先进的dMRI模型比皮质厚度测量更好地检测早期的AD病理和认知衰退.
科学领域:
- 神经成像是一种神经成像.
- 神经退行性疾病 神经退行性疾病
- 生物标志物 生物标志物
背景情况:
- 阿尔茨海默病 (AD) 的病理始于皮质,但早期检测仍然具有挑战性.
- 扩散MRI (dMRI) 提供了对大脑微观结构性质的非侵入性见解.
- 很少有研究探索了高级多dMRI模型,如NODDI和MAP-MRI在AD的皮质中.
研究的目的:
- 研究大脑脊髓液 (CSF) 生物标志物 (pTau181,Aβ1-42) 和皮质dMRI指数 (NODDI,MAP-MRI) 之间的关系.
- 为了比较dMRI测量的灵敏度与皮质厚度在检测早期AD相关的变化.
- 探索dMRI在调解AD生物标志物与认知表现之间的联系中的作用.
主要方法:
- 在阿尔茨海默病神经成像计划中,分析了66名参与者的多层dMRI数据 (NODDI,MAP-MRI) (认知不受损,轻度认知障碍,痴呆症).
- 区域皮层dMRI指数与pTau181和Aβ1-42.4的CSF水平的相关性.
- 将dMRI发现与传统皮质厚度测量结果进行比较,并将其与逻辑记忆性能联系起来.
主要成果:
- 较低的CSF Aβ1-42和较高的pTau181与皮质dMRI测量中的扩散性增加和更少的扩散限制有关.
- 皮层dMRI测量显示与Aβ1-42的关联比pTau181更广泛,与pTau状态相比,Aβ+与Aβ-个体的区别更好.
- dMRI关联调解了CSF生物标志物与逻辑记忆受损之间的关系,表明对早期神经退行症的敏感性.
结论:
- 先进的皮质dMRI指标,特别是那些反映微观结构完整性的指标,对早期阿尔茨海默氏症的病原发生更为敏感,而不是标准的皮质厚度.
- dMRI可以作为一种有价值的工具,用于阐明早期AD认知衰退的机制,以及跟踪微妙的神经退行.
- 这些发现突显了dMRI在非侵入性评估AD相关的微观结构损伤方面的潜力.
更多相关视频
09:31Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
10.7K
08:29Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
Published on: December 18, 2016
14.1K
相关概念视频
01:21Association Areas of the Cortex
5.4K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.4K
03:03Amyloid Fibrils
9.6K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.6K
01:26Alzheimer's Disease: Overview
492
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
492