相关实验视频
Updated: Jul 8, 2025

10:20
Single-cell Profiling of Developing and Mature Retinal Neurons
Published on: April 19, 2012
14.2K
脊椎动物视网膜中神经细胞类型的演变
Joshua Hahn1, Aboozar Monavarfeshani2, Mu Qiao3,4
1Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.
Nature
|December 13, 2023
概括
视网膜细胞类型在脊椎动物中高度保存,进化形成的视网膜最多. 古老的细胞类型,如矮人视网膜质细胞,被重新用于灵长类高敏度视力.
科学领域:
- 神经科学
- 进化生物学
- 基因组学
背景情况:
- 脊椎动物的视网膜具有保存的结构组织,但具有不同的视觉适应性.
- 视网膜细胞类型在应对各种视觉需求时的演变仍未得到充分研究.
研究的目的:
- 系统地研究各种脊椎动物细胞类型的进化保存和变异.
- 识别潜在的视网膜细胞类型及其进化起源的保存基因表达程序.
主要方法:
- 从17种脊椎动物中生成和整合单细胞转录基因图谱.
- 对视网膜细胞类和子类的基因表达模式进行比较分析.
- 识别正体细胞类型及其进化轨迹.
主要成果:
- 主要视网膜细胞类 (光受体,双极细胞,RGC等) 的高分子保存 在物种之间,与进化距离相关的变化.
- 跨物种的众多共享细胞类型的识别,表明古代保存的基因表达程序.
- 从外视网膜到内视网膜的细胞类型的变化增加,表明对视网膜输出的进化压力.
- 发现灵长类矮体RGC的动物正态,揭示了它们的古老起源和灵长类中高敏度视觉的差异扩张.
结论:
- 视网膜细胞类型具有深层次的进化保护,古老的程序支持脊椎动物的共享细胞类型.
- 进化变化在视网膜内部更为明显,特别是在视网膜质细胞中,影响视觉处理.
- 矮人RGC是古老的细胞类型,而不是灵长类动物的创新,
相关概念视频
The Retina
69.1K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
69.1K
Photoreceptors and Visual Pathways
6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K
Anatomy of the Eyeball
7.1K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
7.1K
Nervous Tissue: Neuron Types
2.8K
Neurons, the fundamental units of the nervous system, can be classified based on both their structural and functional characteristics.
Structurally, neurons are categorized into three main types: multipolar, bipolar, and unipolar (or pseudounipolar). Multipolar neurons, which are the most common type in the brain and spinal cord, as well as all motor neurons, possess multiple dendrites and a single axon.
Bipolar neurons, on the other hand, have one primary dendrite and one axon. They are...
Structurally, neurons are categorized into three main types: multipolar, bipolar, and unipolar (or pseudounipolar). Multipolar neurons, which are the most common type in the brain and spinal cord, as well as all motor neurons, possess multiple dendrites and a single axon.
Bipolar neurons, on the other hand, have one primary dendrite and one axon. They are...
2.8K
Vision
53.5K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
53.5K
Neuron Structure
13.0K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
13.0K

