Search

Search

这页已由机器翻译。其他页面可能仍然显示为英文。 View in English

首页
...
研究领域生物科学遗传学基因组结构和调节
成年老鼠大脑的分子细胞结构

成年老鼠大脑的分子细胞结构

Jonah Langlieb ¹, Nina S Sachdev ¹, Karol S Balderrama ¹, Naeem M Nadaf ¹, Mukund Raj ¹, Evan Murray ¹, James T Webber ¹, Charles Vanderburg ¹, Vahid Gazestani ¹, Daniel Tward ², Chris Mezias ³, Xu Li ³, Katelyn Flowers ¹, Dylan M Cable ^1,4, Tabitha Norton ¹, Partha Mitra ³, Fei Chen ^5,6, Evan Z Macosko ^7,8

Jonah Langlieb ¹, Nina S Sachdev ¹, Karol S Balderrama ¹

¹Broad Institute of Harvard and MIT, Cambridge, MA, USA.
²Departments of Computational Medicine and Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
³Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
⁴Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
⁵Broad Institute of Harvard and MIT, Cambridge, MA, USA. chenf@broadinstitute.org.
⁶Harvard Stem Cell and Regenerative Biology, Cambridge, MA, USA. chenf@broadinstitute.org.
⁷Broad Institute of Harvard and MIT, Cambridge, MA, USA. emacosko@broadinstitute.org.
⁸Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. emacosko@broadinstitute.org.

⁰Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Nature +

|

2023年十二月13日

相关实验视频

These videos have been matched automatically. Contact us if they are not relevant.

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Published on: March 8, 2024

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

Published on: August 1, 2022

See all related videos

在PubMed上查看摘要

概括

此摘要是机器生成的。

这项研究使用空间转录学来绘制小鼠大脑细胞类型. 它揭示了高细胞多样性,并为研究大脑疾病提供了框架.

科学领域

神经科学
基因组学
分子生物学

背景情况

哺乳动物的大脑功能取决于特殊的细胞类型及其确切位置.
这些脑细胞的分子特征和空间组织尚未完全理解.

研究的目的

创建一个完整的小鼠大脑细胞类型图谱.
描述每个大脑结构中的细胞类型组成,基因表达和信号.

主要方法

配对高通量单核RNA测序与Slide-seq空间转录组.
在整个小鼠大脑中应用近细胞分辨率方法.

主要成果

为每个神经解剖结构生成详细的细胞类型地图.
在中脑,后脑和下丘脑中发现了高细胞多样性.
开发了对细胞类型的基因接入框架,并描述了信号通路.

结论

鼠标大脑图谱为神经科学研究提供了宝贵的资源.
能够开发出新的遗传工具,帮助对脑疾病研究中的细胞类型进行优先排序.

相关实验视频

这些视频已自动匹配 Contact us 如果它们不相关

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Published on: March 8, 2024

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

Published on: August 1, 2022

See all related videos

Share

X
Facebook
LinkedIn
YouTube

ABOUT JoVE

Overview
Leadership
Blog
JoVE Help Center

AUTHORS

Publishing Process
Editorial Board
Scope & Policies
Peer Review
FAQ
Submit

LIBRARIANS

Testimonials
Subscriptions
Access
Resources
Library Advisory Board
FAQ

RESEARCH

JoVE Journal
Methods Collections
JoVE Encyclopedia of Experiments
Archive

EDUCATION

JoVE Core
JoVE Business
JoVE Science Education
JoVE Lab Manual
Faculty Resource Center
Faculty Site

Terms & Conditions of Use
Privacy Policy
Policies