心血管疾病中的非编码RNA介导基因调节:当前见解和未来方向
Muhammad Abubakar1, Mohsin Hajjaj2, Zil E Zehra Naqvi2
1Department of Internal Medicine, Ameer-Ud-Din Medical College, Lahore General Hospital, Lahore, Punjab, Pakistan. Muhammadabubakar2053@hotmail.com.
Journal of cardiovascular translational research
|December 13, 2023
概括
非编码RNAs (ncRNAs),包括miRNAs,lncRNAs和circRNAs,在心血管疾病 (CVDs) 中至关重要. 了解它们在基因调节中的作用为新的诊断和治疗策略提供了潜力.
科学领域:
- 分子生物学分子生物学
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
背景情况:
- 心血管疾病 (CVDs) 是全球重大健康挑战,需要改进诊断,治疗和预后工具.
- 非编码RNAs (ncRNAs) 越来越多地被认为是它们在复杂的生物过程中的调节作用,包括心血管功能.
研究的目的:
- 在CVDs的背景下,审查当前对选择的ncRNAs,特别是微RNAs (miRNAs),长非编码RNAs (lncRNAs) 和循环RNAs (circRNAs) 的理解.
- 探索这些ncRNAs影响心血管健康和疾病发病的机制.
- 讨论ncRNAs作为CVD生物标志物和治疗点的临床影响和翻译潜力.
主要方法:
- 这项研究是一篇叙事性综述,综合了有关心血管疾病中ncRNAs的现有研究.
- 文献搜索的重点是涉及心血管疾病的miRNAs,lncRNAs和circRNAs,它们的调控功能和临床应用.
- 分析用于研究心血管环境中的ncRNA介导基因调节的方法.
主要成果:
- ncRNAs,包括miRNAs,lncRNAs和circRNAs,在调节基因表达,表观遗传修饰和与心血管疾病相关的信号通路方面发挥着不同的作用.
- 特定的ncRNA已被确定为各种心血管疾病的潜在诊断,治疗和预后指标.
- ncRNAs与心血管健康之间的相互作用是复杂的,涉及复杂的调节网络.
结论:
- 在心血管医学中,ncRNAs代表了开发新型干预措施和改善患者治疗结果的前沿.
- 对ncRNA机制和临床翻译的进一步研究对于实现其在治疗心血管疾病方面的全部潜力至关重要.
- 跨学科的合作对于推进心血管科学中的ncRNA研究领域至关重要.
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