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基基编辑突变基因映射等位基因调整人体T细胞功能

Ralf Schmidt1,2, Carl C Ward3, Rama Dajani4

  • 1Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. ralf.schmidt@meduniwien.ac.at.

Nature
|December 13, 2023
PubMed
概括

研究人员开发了一种基编辑突变发生平台,以确定调节T细胞激活的核酸. 这种方法确定了调节免疫细胞功能的关键氨基酸残留物和域,可能加速免疫疗法设计.

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