针对营养不良儿童的微生物组定向食品中的生物活性糖类
Matthew C Hibberd1,2,3, Daniel M Webber1,2,3, Dmitry A Rodionov4
1Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Nature
|December 13, 2023
概括
这项研究表明,特定的肠道细菌Prevotella copri通过使用特殊食物中的营养物质, 这可以指导更好的食物开发,
科学领域:
- 微生物组研究
- 营养科学
- 儿童健康
背景情况:
- 儿童营养不良与肠道微生物组的乱有关.
- 与传统食物相比,微生物组导向的补充食品 (MDCF-2) 改善了孟加拉儿童的体重增加.
- 了解肠道微生物组的作用对于开发有效的营养干预措施至关重要.
研究的目的:
- 在营养不良儿童中分析肠道微生物对MDCF-2的反应.
- 确定与增长相关的特定细菌种类及其代谢功能.
- 研究食物甘氨酸,细菌代谢和儿童生长之间的关系.
主要方法:
- 从便样本重建1000个细菌基因组 (MAG).
- 对MAG度与体重对长度Z分数 (WLZ) 变化的关联分析.
- 对MAG基因表达的表征和便碳水化合物结构的量化.
- 用特定的甘氨酸对Prevotella copri菌株进行体外生长测试.
主要成果:
- 两种Prevotella copri MAG与WLZ积极相关,并使用了MDCF- 2甘氨酸.
- 在这些MAG中,MDCF-2诱导的代谢途径的表达.
- 细菌酶特异性与糖利用和便碳水化合物结构相关.
结论:
- 在介导MDCF-2的生长效益方面,Prevotella copri发挥着关键作用.
- 通过与生长相关的细菌代谢的生物活性甘氨酸可以为营养不良干预提供信息.
- 这项研究支持针对急性营养不良的食品配方的开发.
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