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干扰素玛释放试验用于查儿童肺结核感染

Huiwen Zheng¹, Jing Xiao¹, Feina Li¹

¹Laboratory of Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Children's Hospital, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

BMC infectious diseases

|December 13, 2023

概括

在儿童诊断潜伏结核病感染方面,X.DOT-TB的性能优于QuantiFERON-TB Gold In-Tube. 诸如男性性别,年龄和潜在疾病等因素增加了测试结果的不确定性.

科学领域:

儿童传染病儿童传染病
诊断免疫学诊断免疫学
结核病研究结核病研究

背景情况:

干扰素-释放试验 (IGRA) 是潜在结核病感染 (LTBI) 诊断的主要工具.
不确定的IGRA结果在儿童中更常见,原因不明.
这项研究比较了儿童群体中的两种IGRA方法.

研究的目的:

为了比较QuantiFERON-TB Gold In-Tube (QFT-GIT) 和X.DOT-TB (XDOT) 在儿童LTBI的诊断性能.
在儿科患者中确定与不确定的IGRA结果相关的风险因素.

主要方法:

一项回顾性研究分析了33662名18岁以下儿童的数据.
患有LTBI或结核病进展风险的儿童用QFT-GIT或X.DOT-TB进行了测试.
在北京儿童医院从2019年8月到2022年8月收集的数据.

主要成果:

X.DOT-TB的阳性率为3.1%,而QFT-GIT的阳性率为1.8%.
在这两种测试中,随着年龄的增长,不确定的IGRA率下降.
在患有呼吸道疾病的儿童中,观察到较高的不确定的和阳性率.

结论:

与QFT-GIT相比,X.DOT-TB在诊断儿科LTBI方面表现优越.
男性的性别,年轻的年龄和特定的潜在疾病与不确定的IGRA结果的更高风险有关.
了解这些风险因素可以帮助优化儿童的LTBI诊断.

关键词:

孩子孩子孩子孩子不确定的不确定的潜在的结核病感染.根据QFT-GIT的说法.XDOT XDOT是指XDOT的意思,是指XDOT的意思.

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