用西治疗的MDD患者的实际临床结果和治疗模式:一项回顾性研究
Brandon T McDaniel1, Victor Cornet1, Jeanne Carroll1
1Parkview Mirro Center for Research and Innovation, 10622 Parkview Plaza Drive, Fort Wayne, IN, 46845, US.
BMC psychiatry
|December 13, 2023
概括
在现实环境中,西改善了患有主要抑郁障碍 (MDD) 的成年人的抑郁症状. 治疗还增强了焦虑,性功能障碍和认知功能,药物持续性高.
科学领域:
- 精神病学和行为科学
- 临床药理学 临床药理学
背景情况:
- 大型抑郁症 (MDD) 是一种普遍的心理健康状况,影响全球数百万人.
- 伏尔托克塞丁是一种抗抑郁药物,已批准用于成人MDD治疗.
- 现实世界的疗效研究对于了解超越受控临床试验的治疗结果至关重要.
研究的目的:
- 评估成年诊断为患有重大抑郁障碍 (MDD) 的患者的伏尔提奥塞丁的实际有效性.
- 通过患者报告的结果测量 (PROMs) 来评估西对抑郁症严重程度和相关症状的影响.
- 检查复杂健康状况的多样化的患者群体中的药物持续性和临床结果.
主要方法:
- 对成年MDD患者的回顾性图表审查,这些患者被处方为西西丁.
- 纳入标准:初次访问,16周内≥2次后续访问 (2014年9月至2018年12月).
- 主要结局:~12周患者健康问卷-9 (PHQ-9) 评分的变化;次要结局包括症状变化,反应,缓解和持续性.
主要成果:
- 包括1242名MDD患者;63.9%的人有≥3个精神病诊断,65.9%的人服用≥3种药物.
- 从基线 (14.15) 到第12周 (9.62;p < 0.001) 的PHQ-9分数显著下降.
- 观察到第12周的应答率 (31.0%) 和缓解率 (23.1%);67%的人继续接受西治疗. 在焦虑,性功能障碍,睡眠,认知和工作/社会功能方面发现了显著的改善.
结论:
- 在现实世界临床实践中,Vortioxetine在改善患有MDD的成年人的抑郁症状方面表现出有效性.
- 该研究群体具有复杂的并发症和治疗史,突出显示了西在具有挑战性的病例中的实用性.
- PROM证实了多个领域的显著改善,支持西在管理MDD中的作用.
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