探索中年住院患者的多病态概况:基于网络的对中国和英国的比较研究
Yining Bao1,2,3, Pengyi Lu1, Mengjie Wang1
1China-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.
BMC medicine
|December 14, 2023
概括
与英国住院患者相比,中国住院患者的多病发病率明显高,疾病网络更复杂. 这凸显了为两种人群量身定制的预防和干预策略的需要,重点关注循环和代谢疾病.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 老年学是指老年学的学科.
背景情况:
- 预防多种疾病在年轻时更有效.
- 了解中年成年人的并发症模式对于有针对性的健康干预至关重要.
- 这项研究比较了中国和英国中年住院患者的并发症模式.
研究的目的:
- 来自中国和英国的中年住院患者的并发症模式的识别和比较.
- 分析这些人群中的多发病性网络的复杂性和特征.
- 为制定量身定制的预防和干预策略提供信息.
主要方法:
- 利用来自西,中国和英国生物库 (40-59岁) 的大量基线住院数据集.
- 采用后勤回归来识别显著的并发病模式 (P < 邦费罗尼校正,流行率> 1/10,000).
- 使用网络分析构建和比较多病症网络,识别枢纽疾病.
主要成果:
- 中国住院患者的多病发病率 (57.12%) 比英国住院患者 (30.39%) 高.
- 中国的多病症网络比英国的网络复杂得多 (2.93倍),影响男性和女性.
- 基本高血压,脂质失调,2型糖尿病和胃炎是常见的枢纽疾病;中国患者患有更多的循环和代谢并发症,而英国患者也患有普遍的消化和泌尿器官并发症.
结论:
- 与英国同行相比,中年中国住院患者的多病发病率和网络复杂性更高.
- 循环和内分泌/营养/代谢疾病是干预这两个人群的关键目标.
- 建议英国人口特别注意消化系统和生殖尿路疾病.
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