甘油三指数与高血压人口中风风险较高有关
Nan Zhang1, Xiying Chi1, Ziyi Zhou2
1Department of Cardiology, Peking University First Hospital, No. 8 Xishiku St, Xicheng District, Beijing, 100034, China.
Cardiovascular diabetology
|December 14, 2023
概括
甘油三糖 (TyG) 指数与高血压患者中风风险增加有关. 年龄显著改变了这种关联,老年人面临更高的风险.
科学领域:
- 心血管医学 心血管医学
- 代谢综合征是代谢综合征的一种.
- 流行病学 流行病学
背景情况:
- 甘油三糖指数 (TyG) 作为胰岛素耐药性的生物标志物.
- 高血压是中风的主要危险因素.
- 了解高血压人群中新型风险预测因素对于初级预防至关重要.
研究的目的:
- 调查TyG指数与首次中风发生率之间的关联.
- 探索年龄作为这种关系中的潜在效果修饰者的作用.
主要方法:
- 使用来自中国中风初级预防试验 (CSPPT) 数据的队列研究设计.
- 这项研究包括来自中国农村地区的7569名高血压患者.
- 计算TyG指数是使用禁食甘油三和葡萄糖水平,并使用Cox比例危险模型进行分析.
主要成果:
- 较高的基线TyG指数水平与首次中风风险增加显著相关.
- 在最高TyG指数四分位数 (≥8.8) 中的人与最低四分位数 (<8.8) 中的人相比,风险增加了1.41倍.
- 观察到TyG指数和年龄之间的显著相互作用,老年人 (≥60岁) 患有高TyG指数 (HR:2.15) 的中风风险最高.
结论:
- 基线TyG指数是高血压患者首次中风的独立预测指标.
- 年龄作为显著的效果修饰剂,放大与高TyG指数相关的中风风险.
- 泰格指数可以帮助识别高风险高血压患者,他们可以从有针对性的预防策略中受益.
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