作为DACH1负面调节的乳腺癌风险因素的S100A8/A9
Xiaojun Zhang1, Mengke Niu2, Tianye Li3
1General Surgery Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi HospitalThird Hospital of Shanxi Medical University, Taiyuan, China.
乳腺癌中S100A8 / A9水平升高预示着预后不佳,特别是在基底类和Her2-过度表达的亚型中. 瘤抑制剂DACH1抑制S100A8/A9,它们的综合水平提供了精确的乳腺癌生存预测.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- S100A8/A9是一种结合蛋白异构体,与炎症和自身免疫性疾病有关.
- 虽然它在乳腺癌中的作用已知,但预后意义和调节机制需要澄清.
研究的目的:
- 调查S100A8/A9在乳腺癌中的预后价值.
- 探索S100A8 / A9和DACH1在乳腺癌中的监管关系.
主要方法:
- 免疫组织化学和ELISA用于量化乳腺癌患者的S100A8/A9蛋白和血清水平.
- 对公共数据库和异种移植模型的分析评估了S100A8/A9mRNA水平和DACH1对瘤生长和S100A8/A9表达的影响.
主要成果:
- 乳腺癌组织中S100A8/A9水平较高,与差异化不良,激素受体损失和Her2阳性相关.
- 升高的S100A8/A9预测患者的预后更差,在侵略性亚型中血清水平更高.
- S100A8/A9mRNA与DACH1相反相关,这抑制了S100A8/A9的表达和瘤的生长.
结论:
- S100A8/A9是基底类和Her2-过度表达乳腺癌预后不佳的重要生物标志物.
- 瘤抑制剂DACH1抑制S100A8 / A9的表达,表明一个治疗点.
- 通过对S100A8/A9和DACH1的综合评估,可以更准确地预测乳腺癌患者的生存率.
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