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代谢功能障碍相关的脂肪肝疾病与系统性动脉样硬化相关联:一个基于社区的横截面研究

Yanli Zhang^1,2, Zhang Xia^3,4, Xueli Cai⁵

¹Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China.

Cardiovascular diabetology

|December 14, 2023

概括

与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 与更广泛的动脉样硬化有关,包括斑块,狭窄和多血管疾病. 脂肪肝疾病 (FLD) 可能是缓解这些心血管风险的干预目标.

科学领域:

心血管医学心血管医学
肝病学肝病学是一种肝病学.
代谢障碍代谢障碍代谢障碍

背景情况:

关于代谢功能障碍相关的脂肪肝疾病 (MAFLD) 和系统性动脉样硬化之间的联系的数据有限.
这项研究调查了MAFLD,动脉样硬化负担 (斑块和狭窄) 和多血管疾病 (PolyVD) 之间的关系.

研究的目的:

检查MAFLD与动脉样硬化斑块和狭窄症的程度之间的关联.
为了确定MAFLD和PolyVD的存在之间的关系.
探索MAFLD亚型对系统性动脉样硬化的影响.

主要方法:

MAFLD的诊断是基于代谢功能障碍 (MD) 和脂肪肝疾病 (FLD).
动脉样硬化被评估在多个血管床使用MRI,CT血管学和脚-手腕指数.
多重血管疾病被定义为至少两个血管部位的狭窄.

主要成果:

调整后的分析显示,MAFLD与斑块 (cOR 2.14) 和狭窄 (cOR 1.47) 的程度更高,与非MAFLD相比,多种疾病 (OR 1.55) 的几率更高.
MAFLD亚型,特别是DM-MAFLD和OW-MAFLD,显示出与动脉样硬化程度和多重疾病的显著关联.
瘦身MAFLD与动脉样硬化斑有关,FLD与MD相互作用,增加了系统性动脉样硬化风险.

结论:

MAFLD及其亚型 (DM-MAFLD,OW-MAFLD) 与增加动脉样硬化斑块,狭窄和多重疾病相关.
脂肪肝疾病 (FLD) 可以作为治疗目标,以减少MAFLD的不良心血管影响.

关键词:

动脉样硬化是一种动脉样硬化.糖尿病是一种糖尿病.脂肪肝疾病是一种脂肪肝疾病.代谢功能障碍代谢功能障碍多血管疾病是多血管疾病.

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