Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

923
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
923
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

1.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.7K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

789
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
789
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

741
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
741
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

68.3K
Overview
68.3K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

501
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
501

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Autoantigen mRNA-LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

The Ste20 kinase TAOK3 restrains Rac-driven cytoskeletal-mitochondrial coupling to preserve naive CD8<sup>+</sup> T cell homeostasis and activation.

Frontiers in immunology·2026
Same author

Pan-cancer single-cell atlases of mouse and human tumor-associated dendritic cells.

Nature communications·2026
Same author

The importance of first-void urine for assessing HPV-specific antibodies: A comparison with midstream urine.

Human vaccines & immunotherapeutics·2026
Same author

Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches.

Immunity·2026
Same author

Protocol to annotate dendritic cell maturation types in vivo making use of lipid nanoparticle-based approaches.

STAR protocols·2026
Same journal

Diversity, Equality, and Inclusion in the naïve T Cell Receptor Repertoire.

Immunological reviews·2026
Same journal

Macrophage Plasticity and Immune Remodeling in Ischemic Heart Failure.

Immunological reviews·2026
Same journal

The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity.

Immunological reviews·2026
Same journal

Tissue-Resident Memory T Cells in the Heart: An Emerging Role in Chronic Inflammation.

Immunological reviews·2026
Same journal

Rethinking Immunity in Tissues: The Biology of Tertiary Lymphoid Structures.

Immunological reviews·2026
Same journal

Inflammation-Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity.

Immunological reviews·2026
查看所有相关文章

相关实验视频

Updated: Jul 8, 2025

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

18.3K

从树突细胞的角度解读免疫细胞死亡.

Sophie Janssens1,2, Sofie Rennen1,2, Patrizia Agostinis3

  • 1Laboratory for ER Stress and Inflammation, Center for Inflammation Research, VIB, Ghent, Belgium.

Immunological reviews
|December 14, 2023
PubMed
概括
此摘要是机器生成的。

癌细胞中的免疫细胞死亡 (ICD),由称为损伤相关分子模式 (DAMPs) 的危险信号标记,对于树突细胞 (DC) 成熟和激活抗瘤免疫力至关重要. 这种相互作用弥合了癌症防御的先天性和适应性免疫力.

关键词:
抗瘤免疫力 免疫力与损伤相关的分子模式.树突细胞是一种树突细胞.免疫性细胞死亡 免疫性细胞死亡这是一种炎症炎症炎症炎症.

更多相关视频

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
11:48

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Published on: May 31, 2018

11.5K
An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

15.3K

相关实验视频

Last Updated: Jul 8, 2025

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

18.3K
Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
11:48

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Published on: May 31, 2018

11.5K
An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

15.3K

科学领域:

  • 免疫学 免疫学 免疫学
  • 癌症生物学 癌症生物学
  • 细胞死亡 细胞死亡

背景情况:

  • 状细胞 (DCs) 是关键的髓状细胞,连接先天性和适应性免疫.
  • DCs向T细胞呈现瘤相关抗原 (TAA),在癌症免疫循环中发挥着至关重要的作用.
  • 瘤细胞死亡必须释放免疫调节信号,而不仅仅是TAA,以实现有效的DC成熟.

研究的目的:

  • 审查树突细胞 (DCs) 如何识别和解释癌细胞接受免疫细胞死亡 (ICD) 的危险信号.
  • 探索DC与癌细胞相互作用对DC功能和抗瘤免疫力的后果.

主要方法:

  • 对免疫细胞死亡 (ICD),损伤相关分子模式 (DAMP) 和树突细胞 (DC) 功能在癌症中的现有文献的审查.
  • 对参与DC感知死亡癌细胞释放的DAMP的信号通路的分析.

主要成果:

  • 癌细胞中的免疫性细胞死亡 (ICD),以病原体模仿和DAMP释放为特征,对于免疫性DC成熟至关重要.
  • DCs从ICD细胞中感知DAMP,从而导致它们的成熟和TAA的有效呈现给T细胞.
  • 这种相互作用促进了对癌症的适应性免疫的参与.

结论:

  • 癌细胞接受ICD和释放DAMP的能力对于通过树突细胞引起强大的抗瘤免疫反应至关重要.
  • 了解ICD信号的DC识别提供了增强抗瘤免疫力的治疗策略.