相关实验视频

Updated: Jul 8, 2025

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Published on: May 10, 2022

通过准Smad3依赖的非编码RNAs来治疗纤维化的治疗潜力

Yue-Yu Gu¹, Xu-Sheng Liu², Hui-Yao Lan³

¹State Key Laboratory of Traditional Chinese Medicine Syndrome, Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Departments of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong; Department of Pharmacology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China; Departments of Nephrology and Pathology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

Molecular therapy : the journal of the American Society of Gene Therapy

|December 14, 2023

概括

向转化生长因子-β (TGF-β) /Smad3相关的非编码RNA (ncRNA) 为慢性病 (CKD) 和纤维化提供了新的治疗策略,解决了有限的治疗选择.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
分子生物学分子生物学
生物化学生物化学

背景情况:

纤维化是慢性病 (CKD) 的一个关键特征,导致功能衰竭.
转化生长因子-β (TGF-β) 是通过正规和非正规途径对纤维化的关键调节者.
斯马德3是TGF-β规范信号传递的中心媒介,并通过非编码RNA (ncRNA) 驱动纤维化.

研究的目的:

审查TGF-β/Smad3相关的ncRNAs在纤维化中的作用.
突出这些ncRNA作为纤维化的潜在生物标志物和治疗点.
讨论这些ncRNAs在治疗纤维化的机制和未来前景.

主要方法:

文献综述侧重于TGF-β信号传导,Smad3和纤维化中的ncRNAs.
对调查特定ncRNAs在纤维化过程中的作用的研究进行分析.
综合当前关于机制和治疗潜力的知识.

主要成果:

Smad3依赖的ncRNAs在调解纤维化方面起着显著的作用.
这些ncRNAs显示出作为诊断和监测纤维化的生物标志物的潜力.
向这些ncRNAs为纤维化提供了一个有前途的治疗途径.

结论:

与TGF-β/Smad3相关的ncRNAs在纤维化的发展中起着关键作用.
这些ncRNAs代表了纤维化的创新生物标志物和治疗点.
对它们机制的进一步研究可能会导致对CKD的新治疗方法.

关键词:

这真是太疯狂了在TGF-β的基础上.没有编码的RNAs.脏纤维化脏纤维化治疗疗法治疗疗法治疗疗法

更多相关视频

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

相关概念视频

TGF - β Signaling Pathway

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...