宿主响应签名趋势在持续的细菌病和转移性感染由于金黄色葡萄球菌和グラム阴性细菌:一个前性的多中心观察性研究
Anna Maria Peri1, Nastaran Rafiei2, Kevin O'Callaghan3
1The University of Queensland, UQ Centre for Clinical Research, Brisbane, Queensland, Australia.
Infectious diseases (London, England)
|December 14, 2023
概括
SeptiScore测定有效地预测了格拉姆阴性细菌病的持续感染,但不能预测金黄色葡萄球菌感染. 这种宿主反应标记有助于排除持续感染,改善败血症诊断.
科学领域:
- 传染性疾病 传染性疾病
- 主体反应生物标志物 主体反应生物标志物
- 临床微生物学 临床微生物学
背景情况:
- 及时诊断细菌病和败血症对于患者的治疗结果至关重要.
- 缺乏可靠的标记物来预测持续性细菌病和转移性感染,这给临床带来了挑战.
- 宿主反应测试SeptiCyte RAPID使用SeptiScore来区分感染性和无菌性炎症.
研究的目的:
- 调查SeptiScore与持续性细菌病和转移性感染风险之间的关联.
- 评估SeptiScore在已被证实由金黄色葡萄球菌或阴性细菌引起的细菌病患者中的有用性.
主要方法:
- 长达14个月的前性多中心观察性研究.
- 包括86名患者,他们已证实有S. aureus或格拉姆阴性细菌菌血症.
- 在连续4天内收集配对血液培养物和SeptiCyte测试样本.
主要成果:
- 与S. aureus菌群相比,Gram-阴性细菌病的SeptiScores显著更高.
- 较高的SeptiScore与积极的随访血液培养和转移性感染相关,在格拉姆阴性细菌病中.
- 在S. aureus细菌血症中,没有发现SeptiScore和结果之间的显著关联.
结论:
- 在S. aureus和格拉姆阴性细菌之间,SeptiScores有所不同.
- 在格拉姆阴性细菌病中,SeptiScore显示了持续感染的良好的负预测值.
- SeptiScore可能有助于排除持久性感染,包括转移性传播或缺乏源控制.
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