慢波睡眠与帕金森病的运动和非运动进展的相关性
Jing Chen1, Danhua Zhao1, Baoyu Chen1
1Department of Neurology, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, 100191, China.
Annals of clinical and translational neurology
|December 14, 2023
概括
较长的深度非快速眼动 (DNREM) 睡眠与帕金森病 (PD) 症状进展的减缓有关. 保持足够的DNREM睡眠可能有助于管理PD患者的运动和非运动症状.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 神经退行性疾病 神经退行性疾病
背景情况:
- 帕金森病 (PD) 是一种进展性神经退行性疾病,影响全球数百万人.
- 睡眠障碍在PD中很常见,影响生活质量和潜在的疾病进展.
- 慢波睡眠,或深度非快速眼动 (DNREM) 睡眠,在恢复过程中起着至关重要的作用.
研究的目的:
- 研究帕金森病患者慢波睡眠时间与运动和非运动症状的进展之间的关系.
- 确定DNREM睡眠持续时间是否是PD症状恶化的预测因素.
主要方法:
- 利用了来自帕金森病进展标记计划 (PPMI) 队列的数据.
- 通过使用Verily Study Watch可穿戴设备客观测量慢波睡眠 (DNREM).
- 评估运动功能 (MDS-UPDRS III,Hoehn和Yahr阶段,步态结,运动波动,运动障碍) 和非运动症状 (抑郁,焦虑,认知,自主功能障碍).
- 雇佣重复测量ANOVA和线性回归用于统计分析.
主要成果:
- 102名PD患者接受了平均3.4年的随访.
- 与较短DNREM睡眠时间 (n=47) 的患者相比,在随访时,较长DNREM睡眠时间 (n=55) 的患者表现出更好的运动功能,更轻微的性功能障碍,以及改善日常生活活动.
- 减少DNREM睡眠时间被确定为PD运动进展的显著风险因素 (β=-0.251,p=0.021).
结论:
- 研究结果表明,在帕金森病中,较长的深度非快速眼动 (DNREM) 睡眠时间和运动和非运动症状的进展速度较慢之间存在显著的关联.
- 充足的慢波睡眠可能是防止PD疾病进展的保护因素.
- 这突显了优化睡眠质量在PD管理中的潜在治疗重要性.
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