胃食道逆流性疾病与阻塞性睡眠呼吸暂停和与睡眠有关的表型的因果关系:双向的双样本孟德尔随机化研究
Shan Qin1, Chi Wang1, Xiaoqiu Wang1
1Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Frontiers in neurology
|December 14, 2023
概括
胃食道逆流性疾病 (GERD) 增加了阻塞性睡眠呼吸暂停 (OSA) 和失眠的风险. 治疗OSA,失眠或打可能会降低GERD的风险,突出一个双向关系.
科学领域:
- 遗传学和睡眠医学 遗传学和睡眠医学
- 胃肠道学和呼吸系统医学
背景情况:
- 胃食道逆流症 (GERD),阻塞性睡眠呼吸暂停 (OSA) 和与睡眠相关的表型 (SRPs) 之间存在复杂的相互作用.
- 由于这些关联的复杂性,在这些关联中建立因果关系的方向是具有挑战性的.
研究的目的:
- 调查GERD和OSA之间的双向因果关系.
- 探索GERD与各种SRP的因果关系,包括失眠,打和睡眠时间.
主要方法:
- 一个双向的门德尔随机化 (MR) 研究,利用全基因组关联研究的总结统计数据.
- 确定满足全基因组显著性和低链接不平衡的仪器变量 (SNP).
- 主要分析采用逆方差加权,敏感性分析包括MR-Egger和强度加权中位数.
主要成果:
- GERD显著增加了OSA (OR=1.53),失眠 (OR=1.14),打 (OR=1.09) 的风险,并减少了睡眠时间 (OR=0.94).
- 反向MR分析显示,OSA (OR=1.07),失眠 (OR=1.95) 和打 (OR=1.74) 与GERD的风险增加有关.
结论:
- 对GERD的遗传倾向增加了失眠,打和OSA的风险,同时减少了睡眠时间.
- 相反,缓解失眠,打或OSA可能会降低患GERD的风险,这表明存在显著的双向联系.
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