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双侧静脉病的病因和听力状况:对315名患者的回顾性研究
Julie Moyaert1,2, Bieke Dobbels1,2, Olivier Peetermans1
1Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Frontiers in neurology
|December 14, 2023
概括
双侧耳道病 (BV) 通常是异常病,影响近四分之三的听力损失患者. 遗传原因,特别是COCH突变,是最常见的,只有21%的听力正常.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经学 神经学
- 遗传学 是一个遗传学.
背景情况:
- 由于治疗选择有限,双边阴道病 (BV) 缺乏足够的研究.
- 了解BV病因和听力状况至关重要,特别是在开发前体植入物时.
- 结合式前庭耳植入器需要关于BV患者听力损失的数据.
研究的目的:
- 确定双边前庭病变 (BV) 的确切和可能的原因.
- 评估诊断为BV的患者的听力状况.
- 在BV患者中分析前庭检测数据.
主要方法:
- 多中心回顾性研究.
- 包括连续的BV患者,符合Bárány学会诊断标准,来自第三级转诊中心.
- 检查前庭测试数据 (热量灌,旋转椅,视频头脉冲测试).
主要成果:
- 确定了315名BV患者;37%的患者有明确的原因,26%的患者有可能的原因,而37%的患者是异常.
- 遗传病因,主要是COCH突变,是最常见的原因 (31%).
- 只有21%的患者听力正常,45%的患者至少有一个耳朵有严重的听力损失.
结论:
- 双边前庭病变 (BV) 是异质的,超过三分之一的病例是特异性的.
- 近四分之三的BV患者有听力损失.
- COCH突变是导致BV的主要非非病变性病因;正常的双边听力很少 (21%).
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