从2007年到2022年对PCSK9抑制剂进行了文献计量分析
Qin Luo1,2, Zhenchu Tang3,4, Panyun Wu1,2
1Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Frontiers in endocrinology
|December 14, 2023
概括
本文献分析揭示了蛋白转化酶亚素/素9型 (PCSK9) 抑制剂的研究趋势越来越强,重点是它们降低胆固醇和心血管事件的有效性. 主要研究领域包括低密度脂蛋白,家族性高胆固醇血症和临床试验.
科学领域:
- 心血管内分泌学 心血管内分泌学
- 药理学 药理学是指药理学的学科.
- 图书统计学 图书统计学
背景情况:
- 2015年批准的蛋白转化酶亚提利辛/凯类型9 (PCSK9) 单克隆抗体引起了人们的极大兴趣.
- 广泛的临床试验证实了PCSK9抑制剂在降低胆固醇和心血管事件风险方面的有效性和安全性.
- 没有任何先前的文献计量分析能够全面评估PCSK9抑制剂的研究环境.
研究的目的:
- 进行PCSK9抑制剂的文献分析.
- 确定该领域的研究趋势和热点.
- 了解研究重点从机制到临床应用的演变.
主要方法:
- 对2007-2022年出版物的图书统计分析.
- 数据来源于网络科学核心集合 (WoSCC) 的数据.
- 使用CiteSpace,Microsoft Excel和Graphpad软件进行的分析.
主要成果:
- 确定了1072个出版物,显示了研究成果的年度增长.
- 美国在出版物方面处于领先地位,其次是英国,加拿大,意大利和法国.
- 主要机构包括哈佛大学和Amgen;顶级作者是Sabatine MS和Giugliano RP.
- 经常同时出现的关键词:"低密度脂蛋白"",家族性高胆固醇血症"",PCSK9抑制剂"",PCSK9"和"有效性".
结论:
- 在过去的15年里,PCSK9抑制剂的研究进展迅速.
- 研究重点已经从降低LDL胆固醇的机制转移到临床试验.
- 目前的研究热点包括冠状动脉疾病和炎症,表明爆炸性生长期.
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