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评估癌症治疗对免疫检查点抑制剂的反应的成像可以在识别低血清炎的过程中作为补充
Anna Galligan1,2,3, Amir Iravani4,5,6, Arian Lasocki4,5
1Immunology and Diabetes Unit, St Vincent's Institute of Medical Research, Melbourne, VIC, Australia.
Frontiers in endocrinology
|December 14, 2023
概括
在组合免疫检查点抑制剂 (cICI) 治疗期间的常规脑部成像可以帮助识别低血压炎. 在成像上检查下垂体变化有助于早期诊断和治疗这种副作用.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
背景情况:
- 免疫检查点抑制组合 (cICI) 治疗的患者中8.5%-14%发生低体质炎.
- 诊断cICI诱导的低性体炎可能是具有挑战性的.
- 这种情况需要在抗CTLA-4/抗PD-1治疗期间进行仔细监测.
研究的目的:
- 评估常规诊断成像在鉴定cICI治疗期间的低体质炎的有用性.
- 为了将成像检测结果与临床诊断标准相关联的hypophysitis.
- 评估成像在监测与cICI相关的垂体变化的作用.
主要方法:
- 用cICI治疗的患者的回顾性队列研究 (2016年1月至2019年1月).
- 对连续脑部MRI,CT和FDG-PET/CT扫描进行分析.
- 对医疗记录进行审查,以诊断低体质炎.
主要成果:
- 31名患者被证实患有下垂体炎的诊断; 20名患者有分离的垂体图像检测结果.
- 下垂体扩大是轻微的和短暂的 (最大13毫米,相对增加7毫米).
- 没有观察到光学隙压缩;高剂量的葡萄皮质类药物在90%的时间内限制了垂体-上腺轴的评估.
结论:
- 在cICI治疗期间的常规成像可以改善hypophyseitis的识别.
- 在成像上监测垂体变化有助于迅速管理.
- 成像在诊断和管理cICI诱导的低血清炎中发挥着至关重要的作用.
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