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在没有代谢综合征的男性中,骨素在减肥期间具有肌肉保护作用:一个多中心,前性,观察性研究
Yi Xiang1, Wenyi Lu1, Xiaomeng Mao1
1Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Frontiers in endocrinology
|December 14, 2023
概括
在没有代谢综合征的人群中,骨质卡 (OC) 在减肥期间保护肌肉质量. 这种效应在男性中更为明显,突出了OC在饮食干预期间保护骨肌肉的作用.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 营养科学 营养科学
背景情况:
- 减肥往往会导致肌肉损失,这在老年人群中尤其令人担忧.
- 骨质素 (OC) 参与能量代谢,并可能防止与年龄相关的肌肉衰退.
- 以前关于OC在肌肉代谢中的作用的研究存在矛盾,通常是由于涉及高血糖患者的研究.
研究的目的:
- 为了研究骨质卡尔辛 (OC) 在减肥期间对肌肉损失的保护作用.
- 专门在没有代谢综合征 (MetS) 的个体中检查这一作用.
主要方法:
- 在130名没有MetS的超重或肥胖参与者中,实施了为期4个月的高蛋白,低能量饮食.
- 在减肥干预之前和之后测量了身体组成和代谢指标.
- 使用相关性和回归分析来评估代谢变化与肌肉质量之间的关系.
主要成果:
- 减肥改善了BMI,体脂百分比,内脏脂肪面积,胰岛素抵抗 (HOMA-IR),HbA1c和脂质概况.
- 干预后骨肌肉百分比 (PSM) 和维生素D水平增加.
- 骨质素 (OC) 水平保持不变,但与PSM呈现正相关性 (r=0.383,p=0.002).
- 经过对混因素进行调整后,OC在男性肌肉质量上表现出显著的保护作用 (β=0.089,p=0.017).
结论:
- 高蛋白质,低能量饮食有效地改善了减肥期间的代谢健康.
- 骨质素 (OC) 在没有MetS的个体,特别是男性减肥期间,在维持肌肉质量方面发挥着保护作用.
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