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鲁坦的重新利用表明对COVID-19疾病的有效治疗

Shavkat I Salikhov¹, Ibrokhim Y Abdurakhmonov², Yuliya I Oshchepkova¹

¹A.S. Sadykov Institute of Bioorganic Chemistry (UzAS), Tashkent, Uzbekistan.

Frontiers in medicine

|December 14, 2023

概括

鲁坦,一种来自皮的口服药物,通过抑制关键的SARS-CoV-2酶,有效地治疗COVID-19. 临床研究表明,成人和儿童的C-反应蛋白减少,病毒病短,COVID-19后症状较少.

科学领域:

药理学药理学是指药理学的学科.
病毒学病毒学
药物重用药物重用

背景情况:

鲁坦是一种口服药物,它来自*Rhus coriaria*,此前已经显示出对多种病毒的抗病毒活性.
在SARS-CoV-2的流行病需要有效和安全的治疗选择.

研究的目的:

评估鲁坦作为COVID-19治疗的重用疗法.
为了研究Rutan对SARS-CoV-2酶的作用机制.
评估Rutan在临床前和临床环境中的安全性和有效性.

主要方法:

针对SARS-CoV-2 3CLpro和RdRp的体外酶抑制试验.
在实验动物中进行临床前研究,以评估疗效和安全性 (药物积累).
在COVID-19的成人和儿科患者中进行临床试验,以评估临床结果和安全性.

主要成果:

在测试剂量 (25,50,100毫克/公斤) 中,鲁坦有效抑制了SARS-CoV-2 3CLpro和RdRp.
在动物器官和组织中没有观察到显著的药物积累,这表明了有利的安全性.
临床研究表明,C-反应蛋白水平和病毒病持续时间的统计显著降低.
与对照组相比,接受鲁坦治疗的患者表现出COVID-19后症状的频率明显较低.

结论:

鲁坦是一种安全有效的药物,用于治疗成人和儿童的COVID-19.
鲁坦对3CLpro和RdRp的双重抑制为对抗SARS-CoV-2提供了一个有前途的治疗策略.
该药物的良好的安全性和降低COVID-19后症状,值得考虑临床使用.

关键词:

3CLpro 3CLpro是什么 3CLpro是什么 3CLpro是什么在 COVID-19 疫情中,RdRpp 在线阅读罗斯·科里亚里亚 (Rhus coriaria) 是一种菜.鲁坦 (Rutan) 是一种关键的方法.这就是SARS-CoV-2病毒.临床试验临床试验临床试验临床试验临床试验

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