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通过关键基因和细胞疗法抑制HIV-1的策略

Alyona Sorokina¹, Elizaveta Anchakova^1,2, Erdem Dashinimaev^1,2

¹Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia.

Frontiers in medicine

|December 14, 2023

概括

新的HIV-1治疗方法显示出对功能性治疗的希望. 本综述探讨了RNA,抗体,细胞和基因组编辑策略,以对抗HIV-1感染和潜藏储存.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

人类免疫缺陷病毒1型 (HIV-1) 感染为正在进行的全球健康挑战,对那些接受联合抗逆转录病毒治疗的人来说,治疗选择有限.
艾滋病毒-1/获得性免疫缺陷综合征 (艾滋病) 的并发症显著减少了预期寿命.
最近基因和基于细胞的策略的进展为HIV-1的功能治疗提供了潜在的潜力.

研究的目的:

审查和分类当前和新兴的HIV-1治疗策略.
探索各种抗HIV-1药物的潜力,以了解和对抗感染.
为潜在的未来HIV-1疗法提供见解.

主要方法:

目前的HIV-1治疗策略的分类.
基于RNA和抗体的治疗方法的审查.
检查细胞和基因组编辑方法.
分析消除潜伏HIV-1储存库的方法.

主要成果:

基因和基于细胞的策略证明了实现功能性HIV-1治疗的希望.
显著患者病例 (柏林,伦敦) 的治疗结果为有效的HIV-1治疗提供了适度的乐观.
这项研究将策略分为RNA/抗体疗法,细胞/基因组编辑和储库消除.

结论:

各种抗HIV-1药物正在提高对HIV-1感染的理解.
这些多样化的治疗方法可能为开发未来有效的HIV-1治疗提供关键的见解.
探索新策略为改善HIV-1管理的结果提供了希望.

关键词:

艾滋病艾滋病艾滋病是什么?CCR5 CCR5 的意思是什么?在CRISPR/Cas9的发现中,发现号码是.艾滋病病毒-1 艾滋病病毒-1 卡特卡特是什么意思

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