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在肠道细菌和真菌微生态系统上,Physalis alkekengi的调节作用

Yanan Yang¹, Xiaohui Zhao², Yong Xie¹

¹Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.

Chinese herbal medicines

|December 14, 2023

概括

植物藻 (PAL) 改变了肠道细菌和真菌的组成. 帕尔丰富有益的细菌和某些真菌,同时减少有害的细菌,这表明它在调节肠道微生物群中的作用.

科学领域:

微生物学微生物学
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

肠道微生物组在人类健康和药物疗效方面发挥着至关重要的作用.
传统中医药Physalis alkekengi (PAL) 已显示出药理学效应,肠道细菌与其作用有关.
帕尔对肠道细菌和真菌群落的特定影响在很大程度上仍未被描述.

研究的目的:

研究Physalis alkekengi (PAL) 对小鼠肠道细菌和真菌种群的调节作用.
在PAL给药后,探索肠道细菌和真菌之间的潜在相互作用.

主要方法:

在C57BL/6小鼠口服水性Physalis alkekengi (PAL) 提取物四周内.
使用全长的16S rRNA和ITS1/2基因测序来分别分析肠道细菌和真菌种群.

主要成果:

使用PAL丰富了有益细菌 (例如,Duncaniella,Kineothrix) 并减少了促炎性细菌 (例如,Mucispirillum).
PAL增加了某些真菌 (例如,阿斯伯吉勒斯,克拉多斯波里亚,阿尔特纳里亚) 的丰富性,同时减少了其他真菌 (例如,Penicillium).
相关性分析揭示了两个不同的微生物群;第一组 (PAL-丰富) 显示了特定细菌和真菌之间的正相关性,而第二组 (丰富) 也显示了王国间的相关性.

结论:

这项研究提供了Physalis alkekengi (PAL) 调节肠道细菌和肠道真菌的能力的初步证据.
这些发现表明,PAL对肠道微生物群的影响可能有助于其已知的药理机制.

关键词:

菲萨利斯 (Physalis alkekengi L.) 是一种植物.我们的肠道细菌是肠道细菌.肠道的真菌肠道的真菌微生态系统的微生态系统传统的中国医药传统的中国医药.

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