来自Allium chinense的两个新的胺
Xiaoqing Li1, Shikai Yan1, Jihong Lu1
1Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Chinese herbal medicines
|December 14, 2023
概括
从Allium chinense灯泡中分离了两个新的胺. 化合物3-英多尔甲在体外证明了对心肌细胞对氧化损伤的显著保护.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 心血管研究研究心血管研究
背景情况:
- ,通常被称为中国洋,传统上用于药用目的.
- 胺是一种具有多种生物活动的化合物.
- 心肌损伤是一个重大的健康问题,需要寻找新的保护剂.
研究的目的:
- 从Allium chinense灯泡中分离和识别胺.
- 评估这些化合物在保护心肌细胞免受损伤方面的潜力.
主要方法:
- 植物化学分析涉及凝和Sephadex LH-20列染色学,以及高性能液体染色学 (HPLC).
- 使用核磁共振 (NMR) 谱学和质谱学进行结构阐明.
- 使用暴露于过氧化 (H2O2) 的H9c2细胞进行心肌保护作用的体外评估.
主要成果:
- 分离了两种新型胺,阿利胺I (1) 和阿利胺II (2),以及六种已知的化合物.
- 已知的化合物被确定为3 - 印多甲基 (3),1 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 2,3,4,9-四水-1H-皮里多,3 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- 化合物3 (3-英多尔甲) 在50μmol/L显著抑制H9c2细胞损伤引起的H2O2.2.
结论:
- 酸灯泡含有新型和已知的胺.
- 3 - 印度醇碳甲 (3) 在体外表现出显著的心肌保护活性.
- 这项研究确定了3-英多尔碳化物作为来自Allium chinense的潜在治疗成分,用于心肌保护.
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