丹麦人口中的结肠直肠状病变和息肉:一项基于全国登记册的大型队列研究
Mille Andrea1, Rikke Karlin Jepsen1, Mads Falk Klein2,3
1Department of Pathology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
Endoscopy international open
|December 14, 2023
概括
结肠直肠形多体 (SPs) 正在增加,特别是形形病变 (SSLs). 虽然最近SP的总体数量稳定下来,但SSL的比例继续上升,同步病变很常见.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 结肠直肠状病变和多体 (SPs) 包括高可塑性多体 (HP),带有或没有发育不良的状状病变 (SSL/SSL-D) 和传统的状腺瘤 (TSA).
- SPs涉及20%至30%的结直肠癌 (CRC).
- 本研究研究了丹麦人口中SPs的发病率和特征.
研究的目的:
- 在丹麦队列中确定结直肠状病变和多 (SPs) 的发生率和基线特征.
- 分析SP亚型,解剖位置和随时间变化的趋势.
主要方法:
- 在2000年至2021年期间,使用了丹麦病理学注册表对所有病理学专科医生的数据.
- 数据链接使用唯一的个人识别号码,SNOMED代码,年龄,性别和程序日期.
- 计算了SP亚型的发病率和分析了时间变化.
主要成果:
- 在2000年至2021年期间,在163,840名患者中,共确定了292,761名SP.
- 从2000年到2021年,SP的总体发病率大幅增加,SSS的比例显著上升,从2006年的1.7%上升到2021年的38%.
- 同步病变,包括常规腺瘤,是常见的,3.3%的手术显示CRC与SPs.
结论:
- 结肠直肠形息肉 (SP) 的发病率正在增加,特别是形形病变 (SSL) 的增加.
- 虽然SP的总数似乎在2019-2021年稳定下来,SSL的比例继续增长.
- 在所有SP亚型中,同步病变是常见的,这凸显了彻底内镜检查的重要性.
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