暴露于歧视影响食品线索的不健康加工:大脑和肠道之间的交叉通话
Xiaobei Zhang1,2,3,4, Hao Wang1,5, Lisa A Kilpatrick1,2,3,4
1G. Oppenheimer Center for Neurobiology of Stress and Resilience, UCLA, Los Angeles, CA, USA.
Nature. Mental health
|December 14, 2023
概括
歧视暴露增加了大脑对食物线索的反应性,并破坏了大脑-肠道-微生物系统,可能导致不健康的饮食和肥胖. 这些发现突出了新的途径,将压力与体重增加联系起来.
科学领域:
- 神经科学是一个神经科学.
- 微生物组研究的研究.
- 在健康方面存在差异.
背景情况:
- 歧视与肥胖等不良健康结果有关,但根本机制尚未完全理解.
- 了解社会压力因素如何影响生理系统对于公共卫生至关重要.
研究的目的:
- 调查歧视对大脑对食物线索的反应性的影响.
- 探索大脑-肠-微生物系统中相关的调节障碍.
- 找出潜在的机制,将歧视与肥胖风险联系起来.
主要方法:
- 多omics分析整合神经成像和便代谢物数据.
- 评估大脑对食物图像的反应.
- 对肠道微生物组和代谢物概况的分析.
主要成果:
- 歧视暴露与奖励和执行控制大脑区域对食物暗示的反应性增加有关.
- 观察到与氧化应激和炎症相关的改变的谷氨酸途径代谢物.
- 大脑和肠道特征之间的关联对于不健康的甜食特别明显.
结论:
- 歧视起到压力作用,可以增强食物的反应性,并破坏大脑-肠-微生物群轴.
- 这些干扰可能会促进不健康的饮食行为,增加肥胖风险.
- 针对这些神经生物学和肠道变化,可以为与歧视相关的压力和肥胖提供新的治疗策略.
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