在帕金森病中解开编程神经适应深度大脑刺激神经系统的复杂性
Kevin B Wilkins1, Jillian A Melbourne1, Pranav Akella1
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
Frontiers in human neuroscience
|December 14, 2023
概括
适应性深度大脑刺激 (aDBS) 通过根据实时生物标志物调整治疗,为帕金森病 (PD) 提供了潜在的治疗机会. 优化编程参数是有效实施aDBS的关键.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 神经学 神经学
背景情况:
- 帕金森病 (PD) 的深度大脑刺激 (DBS) 传统上使用了连续的开放循环刺激.
- 最近的技术进步允许闭环自适应DBS (aDBS),其中刺激可以动态调整.
- aDBS有望改善PD的运动症状管理.
研究的目的:
- 概述编程自适应性深度大脑刺激 (aDBS) 参数的关键考虑因素.
- 突出实时生物标志物和控制政策在aDBS中的重要性.
- 讨论影响aDBS性能的辅助参数.
主要方法:
- 基于使用aDBS支持的研究神经刺激器的经验的观点.
- 专注于识别可靠的实时生物标志物,以适应性控制.
- 分析辅助编程参数,如适应窗口和速率.
主要成果:
- 成功的aDBS依赖于确定强大的生物标志物和有效的控制政策.
- 辅助参数,如适应时间和速度,显著影响aDBS的性能.
- 参数优化取决于患者和控制政策.
结论:
- 编程aDBS的标准化协议对于临床翻译至关重要.
- 需要进一步的研究,以最大限度地提高适应性深度大脑刺激对帕金森病的益处.
- aDBS需要仔细考虑核心和辅助编程参数.
更多相关视频
06:32Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring
Published on: July 14, 2023
1.3K
12:04Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
Published on: January 6, 2011
13.0K
相关概念视频
Parkinson's Disease: Treatment
274
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
274
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
Parkinson's Disease: Overview
556
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
556
