儿童多器官损伤相关的危险因素-系统性红血性狼发病
Thanaporn Puengpipattrakul1, Butsabong Lerkvaleekul2, Kwanchai Pirojsakul3
1Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Frontiers in pediatrics
|December 14, 2023
概括
儿童开始的全身性红斑狼 (cSLE) 可以导致器官损伤. 高度的疾病活性,感染和mycophenolate mofetil使用是cSLE患者发展不可逆转损伤的关键风险因素.
科学领域:
- 类风湿病学 类风湿病学
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
背景情况:
- 儿童开始的全身性红斑狼 (cSLE) 影响许多器官,39%-65%的患者经历损伤.
- 对于cSLE中器官损伤的风险因素尚未确立,特别是在亚洲人群中.
研究的目的:
- 评估cSLE患者器官损伤的发生率.
- 为了确定与cSLE中累积器官损伤相关的风险因素.
主要方法:
- 在2008年至2020年期间,对134名被诊断患有cSLE的患者进行了回顾性研究.
- 收集了关于基线特征,治疗和疾病活性 (SLEDAI-2K) 的数据.
- 使用系统性狼国际合作诊所/美国风湿病学学院损伤指数 (SDI) 评估器官损伤.
主要成果:
- 29.9%的患者有不可逆转的器官损伤 (SDI>1),发病率为每100人年5.7人.
- 眼睛,肌肉骨和神经损伤是最常见的.
- 较高的疾病活性 (SLEDAI-2K ≥12),感染和mycophenolate mofetil使用预测器官损伤 (ORs 3.19-3.73).
结论:
- 器官损伤是cSLE的一个重大问题.
- 高初始疾病活性,感染和mycophenolate mofetil使用是关键的危险因素.
- 意识和监测对于管理有风险的cSLE患者至关重要.
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