严重脑的儿童的骨健康
Vincent Barbier1,2,3,4, Vincent Goeb5, Richard Gouron4,6
1Department of Paediatric Physical Medicine and Rehabilitation, Amiens University Hospital and Jules Verne University of Picardie, Amiens, France.
Frontiers in pediatrics
|December 14, 2023
概括
患有严重脑的儿童表现出骨健康不佳,骨矿物质密度低,可能是由于骨过度重塑造成的. 管理应该解决体重不足和青春期延迟的问题,可能需要补充和维生素D.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 整形外科 整形外科 整形外科
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 严重的脑 (CP) 与显著的运动障碍有关.
- 骨健康并发症在患有CP的儿童中很常见,影响他们的生活质量和长期预后.
研究的目的:
- 为了描述严重的CP的儿童的骨健康状况.
- 在这个人群中确定与骨健康相关的因素.
主要方法:
- 回顾性,单中心研究.
- 骨综合性评估,包括临床评估,骨矿物密度 (BMD) 测量 (全身减去头部和腰椎的BMC和BMDZ分数),以及骨生物标志物分析.
- 统计分析以确定骨健康参数与临床因素 (年龄,体重,青春期阶段) 之间的关系.
主要成果:
- 所有19名患有严重脑膜炎的儿童都有异常的骨矿物质含量 (BMC) Z分数.
- 观察到低骨矿物质密度 (BMD) 的高患病率,只有一个儿童的 BMD Z 分数大于 -2 总体减去头部.
- 骨生物标志物数据表明骨过度重塑,尽管标志物水平与密度计变量无关. 年龄,体重和青春期阶段与骨质量有显著的关联.
结论:
- 患有严重肌肉衰竭的儿童随着年龄增长而缺乏足够的骨质积累,这可能与过度的骨重塑有关.
- 低骨矿物质密度在这个队列中非常普遍.
- 干预措施,如补充和维生素D,以及管理体重不足和青春期延迟,可能是有益的. 骨头重塑标记物可能有助于监测.
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