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多个系统缩中的疼痛系统性审查和元分析
Nicole Campese1, Bianca Caliò1,2, Fabian Leys1
1Department of Neurology Medical University of Innsbruck Innsbruck Austria.
Movement disorders clinical practice
|December 14, 2023
概括
疼痛是多重系统缩 (MSA) 中常见但未被认可的问题,影响了67%的患者. 这种常见的非运动性症状,特别是在帕金森症的MSA中,往往未得到充分治疗,这突显了需要更好的检测和管理策略的需要.
科学领域:
- 神经学 神经学
- 临床研究 临床研究
- 系统审查是系统的审查.
背景情况:
- 疼痛是多个系统缩 (MSA) 中经常报告的非运动症状.
- 这种症状在MSA的背景下仍然被研究得很少.
- 了解MSA中的疼痛对于改善患者护理至关重要.
研究的目的:
- 评估多重系统缩 (MSA) 患者疼痛的发生率.
- 描述特征并确定与MSA疼痛相关的风险因素.
- 评估MSA患者疼痛的当前治疗策略.
主要方法:
- 在PubMed,Cochrane和Web of Science数据库中进行了系统的文献搜索.
- 在2022年9月30日之前以英语出版的研究使用PRISMA指南进行了选.
- 关键词包括"疼痛"",多系统缩"",MSA"和相关术语. 从13项研究中对1236名MSA个体的数据进行了定量分析.
主要成果:
- 在多个系统缩 (MSA) 中,疼痛的综合患病率为67% (95% CI: 57%-75%).
- 与小脑类型 (45%) 相比,患有帕金森症特征的MSA患者 (76%) 的疼痛患病率显著更高.
- 疼痛评估方法异质,只有半数患有疼痛的MSA患者接受了向治疗.
结论:
- 疼痛是一种普遍存在但未得到充分承认和治疗的多系统缩 (MSA) 的非运动性症状.
- 进一步的研究对于提高MSA患者的疼痛检测和管理协议至关重要.
- 改善疼痛评估和治疗对于解决这种重要的非运动特征至关重要.
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