在怀孕期间使用低分子量肝素的机械大动脉血栓栓塞
Rebecca Philpott1, Cassandra Voong2, Khalil Jalkh2
1Eisenhower Army Medical Center, Fort Gordon, Augusta, Georgia, USA.
JACC. Case reports
|December 14, 2023
概括
在具有机械大动脉的孕妇中,低分子量肝素的次治疗剂量可以导致血栓形成. 基于生理变化和血液水平的个性化剂量对有效的抗凝血至关重要.
科学领域:
- 心脏病学 心脏病学
- 产科 产科 产科 产科 产科
- 药理学 药理学是指药理学的学科.
背景情况:
- 机械大动脉需要抗凝剂,尤其是在怀孕期间.
- 怀孕涉及显著的生理变化,影响药物的药理动力学.
- 亚治疗性抗凝剂存在风险,包括血栓栓塞事件.
研究的目的:
- 报告怀孕期间由于抗凝不充分而导致的机械大动脉血栓的病例.
- 为了突出个性化低分子量肝素在孕妇患者的剂量的重要性.
主要方法:
- 一个31岁的孕妇的病例报告.
- 对抗凝血药物管理和结果的审查.
主要成果:
- 尽管接受了低分子量肝素治疗,但在机械大动脉上形成了血栓.
- 治疗被切换为静脉注射肝素,然后华法林.
结论:
- 低分子量肝素在怀孕期间的剂量必须是个性化的.
- 剂量应考虑到患者的体重和生理变化.
- 治疗药物监测对于优化抗凝血和预防并发症至关重要.
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